Human Follicle-Stimulating Hormone Complexed with its Receptor

Disease
Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[136530], Ovarian dysgenesis 1 OMIM:[136435], Ovarian hyperstimulation syndrome OMIM:[136435], Ovarian response to FSH stimulation OMIM:[136435], Ovarian sex cord tumors OMIM:[136435]

About this Structure
1XWD is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

The leucine-rich domain of the receptor has a characteristic bowed shape due to harboring a series of leucine-rich repeats ; leucine-rich repeats often are horseshoe- or arc-shaped.   

Add about cysteine-knot.  Add about seat belt.

External Resources

 * Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors

Page originally seeded at 1xwd by OCA on Tue Feb 17 21:34:49 2009